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D’abord intitulée « Syndrome de la Marionnette Joyeuse » en raison de la gaieté excessive et de la démarche de pantin des enfants atteints, cette maladie porte enfin aujourd’hui le nom de son découvreur, le Dr. Harry Angelman, qui, le premier, sut regrouper des symptômes pour en dégager un syndrome. En 1965, ce pédiatre anglais décrivit pour la première fois trois enfants présentant les caractéristiques maintenant connues comme appartenant au syndrome d’Angelman.Laissons-lui la parole : 

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Harry Angelman

L’histoire de la médecine est pleine d’histoires intéressantes à propos de la découverte de maladies. La saga du Syndrome d’Angelman est une de ces histoires. Ce fut purement par hasard qu’il y a une trentaine d’années, trois enfants handicapés furent admis, à différentes périodes, dans mon service de pédiatrie, en Angleterre. Ils présentaient diverses incapacités et, bien qu’au premier coup d’œil, ils semblaient souffrir de pathologies différentes, je sentis qu’il y avait une cause commune pour leur maladie. Le diagnostic était purement clinique parce que, malgré les investigations techniques, qui sont aujourd’hui plus affinées, je fus incapable d’établir la preuve scientifique que ces trois enfants présentaient le même handicap. C’est pourquoi, j’hésitai à écrire à leur propos dans les publications médicales.  Cependant, alors que j’étais en vacances en Italie, je découvris une toile dans le musée de Castelvecchio de Vérone, intitulée « Le Garçon à la Marionnette ». Le visage souriant du garçon et le fait que mes trois patients montraient des mouvements saccadés me donna l’idée d’écrire un article sur eux avec comme titre « Puppet Children » (« Enfants Marionnettes »). Ce nom ne plut pas aux parents mais il servit cependant à regrouper les trois enfants sous un seul syndrome. Plus tard, ce nom fut changé en « Syndrome d’Angelman ». Cet article parut en 1965 mais, après avoir suscité quelque intérêt, il fut quasi oublié jusqu’au début des années ’80.

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1/1 RuntimeException in FileProfilerStorage.php line 143: Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/2f/23).

  1. in FileProfilerStorage.php line 143
  2. at FileProfilerStorage->write(object(Profile)) in Profiler.php line 104
  3. at Profiler->saveProfile(object(Profile)) in ProfilerListener.php line 152
  4. at ProfilerListener->onKernelTerminate(object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
  5. at call_user_func(array(object(ProfilerListener), 'onKernelTerminate'), object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher)) in WrappedListener.php line 61
  6. at WrappedListener->__invoke(object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
  7. at call_user_func(object(WrappedListener), object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher)) in classes.php line 1888
  8. at EventDispatcher->doDispatch(array(object(WrappedListener), object(WrappedListener)), 'kernel.terminate', object(PostResponseEvent)) in classes.php line 1803
  9. at EventDispatcher->dispatch('kernel.terminate', object(PostResponseEvent)) in TraceableEventDispatcher.php line 133
  10. at TraceableEventDispatcher->dispatch('kernel.terminate', object(PostResponseEvent)) in HttpKernel.php line 77
  11. at HttpKernel->terminate(object(Request), object(Response)) in Kernel.php line 151
  12. at Kernel->terminate(object(Request), object(Response)) in app_dev.php line 30
Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/2f/23). (500 Internal Server Error)
Exception detected!

Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/2f/23).

500 Internal Server Error - RuntimeException

Stack Trace

  1. in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/FileProfilerStorage.php at line 143  -
    1.             // Create directory
    2.             $dir dirname($file);
    3.             if (!is_dir($dir) && false === @mkdir($dir0777true) && !is_dir($dir)) {
    4.                 throw new \RuntimeException(sprintf('Unable to create the storage directory (%s).'$dir));
    5.             }
    6.         }
  2. at FileProfilerStorage ->write (object(Profile))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/Profiler.php at line 104  +
  3. at Profiler ->saveProfile (object(Profile))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/EventListener/ProfilerListener.php at line 152  +
  4. at ProfilerListener ->onKernelTerminate (object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
  5. at call_user_func (array(object(ProfilerListener), 'onKernelTerminate'), object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
    in vendor/symfony/symfony/src/Symfony/Component/EventDispatcher/Debug/WrappedListener.php at line 61  +
  6. at WrappedListener ->__invoke (object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
  7. at call_user_func (object(WrappedListener), object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
    in app/cache/dev/classes.php at line 1888  +
  8. at EventDispatcher ->doDispatch (array(object(WrappedListener), object(WrappedListener)), 'kernel.terminate', object(PostResponseEvent))
    in app/cache/dev/classes.php at line 1803  +
  9. at EventDispatcher ->dispatch ('kernel.terminate', object(PostResponseEvent))
    in vendor/symfony/symfony/src/Symfony/Component/EventDispatcher/Debug/TraceableEventDispatcher.php at line 133  +
  10. at TraceableEventDispatcher ->dispatch ('kernel.terminate', object(PostResponseEvent))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/HttpKernel.php at line 77  +
  11. at HttpKernel ->terminate (object(Request), object(Response))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Kernel.php at line 151  +
  12. at Kernel ->terminate (object(Request), object(Response))
    in app_dev.php at line 30  +

Logs  -

1 error
  1. INFO - Matched route "angelman_homepage".
  2. INFO - Populated the TokenStorage with an anonymous Token.
  3. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure".
  4. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelRequest".
  5. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest".
  6. DEBUG - Notified event "kernel.request" to listener "Symfony\Bundle\FrameworkBundle\EventListener\SessionListener::onKernelRequest".
  7. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\FragmentListener::onKernelRequest".
  8. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest".
  9. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest".
  10. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelRequest".
  11. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\Security\Http\Firewall::onKernelRequest".
  12. DEBUG - Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController".
  13. DEBUG - Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController".
  14. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController".
  15. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController".
  16. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController".
  17. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelController".
  18. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController".
  19. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse".
  20. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse".
  21. DEBUG - Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse".
  22. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse".
  23. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SaveSessionListener::onKernelResponse".
  24. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse".
  25. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest".
  26. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelFinishRequest".
  27. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest".
  28. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\Security\Http\Firewall::onKernelFinishRequest".
  29. DEBUG - mkdir(): Disk quota exceeded
  30. CRITICAL - Uncaught PHP Exception RuntimeException: "Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/2f/23)." at /home/atsartn/public_html/vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/FileProfilerStorage.php line 143
  31. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure".
  32. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelRequest".
  33. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest".
  34. DEBUG - Notified event "kernel.request" to listener "Symfony\Bundle\FrameworkBundle\EventListener\SessionListener::onKernelRequest".
  35. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\FragmentListener::onKernelRequest".
  36. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest".
  37. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest".
  38. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelRequest".
  39. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\Security\Http\Firewall::onKernelRequest".
  40. DEBUG - Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController".
  41. DEBUG - Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController".
  42. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController".
  43. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController".
  44. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController".
  45. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelController".
  46. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController".

Stack Trace (Plain Text)  +