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Dans les années ’80, ce syndrome était considéré comme rarissime. Depuis, avec les belles avancées de la médecine, il a été possible de mieux cerner ce syndrome, de dégager des caractéristiques physiques, comportementales, électroencéphalographiques, tandis que la génétique permettait de trouver « la preuve scientifique » tant attendue. Depuis, le nombre de cas diagnostiqués n’a cessé de grimper : aujourd’hui, en général, on diagnostique plus et plus tôt.

Différentes études épidémiologiques ont été menées afin d’estimer l’incidence de cette maladie  : sa prévalence oscille entre 1/12.000 et 1/20.000. Le syndrome d’Angelman a été reporté partout dans le monde, au travers de tous les groupes raciaux, et dans les deux sexes. La « Angelman Syndrome Foundation » a recensé quelque 2.000 cas aux USA ; pourtant, si l’on prend en compte une prévalence de 1 /20.000, les estimations indiquent que pour l’Amérique du Nord (USA + Canada), on devrait s’attendre à quelque 15.000 cas ! Pour l’Amérique du Sud 24.000 cas, 50.000 pour l’Europe, 35.000 pour l’Afrique, 2.800 pour l’Australie, 165.000 pour l’Asie. Cela fait un total mondial d’environ 285.000 cas (estimations 2002). Ces chiffres démontrent que le syndrome d’Angelman n’est pas, à l’échelle mondiale, une maladie aussi rare que les médecins le pensaient au moment de sa découverte. Cela démontre aussi qu’elle n’est pas encore suffisamment diagnostiquée.

En Tunisie, on recense une centaine d’ « anges », nom souvent attribué aux enfants Angelman, mais ce syndrome étant méconnu, tous les cas ne sont pas diagnostiqués. En effet, si l’on considère que la Tunisie compte un peu plus de dix millions d’habitants, et que l’on prend en compte une prévalence de 1/20.000, on devrait trouver plus de 500 cas. La seule explication est bien le non-diagnostic. Ainsi, aujourd’hui encore, de nombreux enfants atteints du syndrome d’Angelman sont, par exemple, erronément diagnostiqués comme autistes du fait de leur absence de langage.

Whoops, looks like something went wrong.

1/1 RuntimeException in FileProfilerStorage.php line 143: Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/6e/9d).

  1. in FileProfilerStorage.php line 143
  2. at FileProfilerStorage->write(object(Profile)) in Profiler.php line 104
  3. at Profiler->saveProfile(object(Profile)) in ProfilerListener.php line 152
  4. at ProfilerListener->onKernelTerminate(object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
  5. at call_user_func(array(object(ProfilerListener), 'onKernelTerminate'), object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher)) in WrappedListener.php line 61
  6. at WrappedListener->__invoke(object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
  7. at call_user_func(object(WrappedListener), object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher)) in classes.php line 1888
  8. at EventDispatcher->doDispatch(array(object(WrappedListener), object(WrappedListener)), 'kernel.terminate', object(PostResponseEvent)) in classes.php line 1803
  9. at EventDispatcher->dispatch('kernel.terminate', object(PostResponseEvent)) in TraceableEventDispatcher.php line 133
  10. at TraceableEventDispatcher->dispatch('kernel.terminate', object(PostResponseEvent)) in HttpKernel.php line 77
  11. at HttpKernel->terminate(object(Request), object(Response)) in Kernel.php line 151
  12. at Kernel->terminate(object(Request), object(Response)) in app_dev.php line 30
Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/6e/9d). (500 Internal Server Error)
Exception detected!

Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/6e/9d).

500 Internal Server Error - RuntimeException

Stack Trace

  1. in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/FileProfilerStorage.php at line 143  -
    1.             // Create directory
    2.             $dir dirname($file);
    3.             if (!is_dir($dir) && false === @mkdir($dir0777true) && !is_dir($dir)) {
    4.                 throw new \RuntimeException(sprintf('Unable to create the storage directory (%s).'$dir));
    5.             }
    6.         }
  2. at FileProfilerStorage ->write (object(Profile))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/Profiler.php at line 104  +
  3. at Profiler ->saveProfile (object(Profile))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/EventListener/ProfilerListener.php at line 152  +
  4. at ProfilerListener ->onKernelTerminate (object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
  5. at call_user_func (array(object(ProfilerListener), 'onKernelTerminate'), object(PostResponseEvent), 'kernel.terminate', object(TraceableEventDispatcher))
    in vendor/symfony/symfony/src/Symfony/Component/EventDispatcher/Debug/WrappedListener.php at line 61  +
  6. at WrappedListener ->__invoke (object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
  7. at call_user_func (object(WrappedListener), object(PostResponseEvent), 'kernel.terminate', object(ContainerAwareEventDispatcher))
    in app/cache/dev/classes.php at line 1888  +
  8. at EventDispatcher ->doDispatch (array(object(WrappedListener), object(WrappedListener)), 'kernel.terminate', object(PostResponseEvent))
    in app/cache/dev/classes.php at line 1803  +
  9. at EventDispatcher ->dispatch ('kernel.terminate', object(PostResponseEvent))
    in vendor/symfony/symfony/src/Symfony/Component/EventDispatcher/Debug/TraceableEventDispatcher.php at line 133  +
  10. at TraceableEventDispatcher ->dispatch ('kernel.terminate', object(PostResponseEvent))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/HttpKernel.php at line 77  +
  11. at HttpKernel ->terminate (object(Request), object(Response))
    in vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Kernel.php at line 151  +
  12. at Kernel ->terminate (object(Request), object(Response))
    in app_dev.php at line 30  +

Logs  -

1 error
  1. INFO - Matched route "angelman_incidence".
  2. INFO - Populated the TokenStorage with an anonymous Token.
  3. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure".
  4. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelRequest".
  5. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest".
  6. DEBUG - Notified event "kernel.request" to listener "Symfony\Bundle\FrameworkBundle\EventListener\SessionListener::onKernelRequest".
  7. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\FragmentListener::onKernelRequest".
  8. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest".
  9. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest".
  10. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelRequest".
  11. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\Security\Http\Firewall::onKernelRequest".
  12. DEBUG - Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController".
  13. DEBUG - Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController".
  14. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController".
  15. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController".
  16. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController".
  17. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelController".
  18. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController".
  19. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse".
  20. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse".
  21. DEBUG - Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse".
  22. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse".
  23. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SaveSessionListener::onKernelResponse".
  24. DEBUG - Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse".
  25. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest".
  26. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelFinishRequest".
  27. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest".
  28. DEBUG - Notified event "kernel.finish_request" to listener "Symfony\Component\Security\Http\Firewall::onKernelFinishRequest".
  29. DEBUG - mkdir(): Disk quota exceeded
  30. CRITICAL - Uncaught PHP Exception RuntimeException: "Unable to create the storage directory (/home/atsartn/public_html/app/cache/dev/profiler/6e/9d)." at /home/atsartn/public_html/vendor/symfony/symfony/src/Symfony/Component/HttpKernel/Profiler/FileProfilerStorage.php line 143
  31. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure".
  32. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelRequest".
  33. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest".
  34. DEBUG - Notified event "kernel.request" to listener "Symfony\Bundle\FrameworkBundle\EventListener\SessionListener::onKernelRequest".
  35. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\FragmentListener::onKernelRequest".
  36. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest".
  37. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest".
  38. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\TranslatorListener::onKernelRequest".
  39. DEBUG - Notified event "kernel.request" to listener "Symfony\Component\Security\Http\Firewall::onKernelRequest".
  40. DEBUG - Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController".
  41. DEBUG - Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController".
  42. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController".
  43. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController".
  44. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController".
  45. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelController".
  46. DEBUG - Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController".

Stack Trace (Plain Text)  +